• br Conflict of interest br Introduction

  2023-07-25

  

  Conflict of interest Introduction Colorectal cancer (CRC) is one of the major cause of tumor-related morbidity and mortality worldwide. Poor prognosis and consequences of its metastatic spread make CRC the second most common cause of cancer-related deaths in western countries [1]. Apart from o

• br Aldehyde sensors to monitor substrate levels Previous

  2023-07-25

  

  Aldehyde sensors to monitor substrate levels Previous efforts to ameliorate metabolic diseases frequently relied on biochemical methods which could measure the levels of toxic substrates in g15 or bodily fluids (blood and serum or plasma, urine, cerebrospinal fluid). Therapeutic efforts to decrea

• PQ 401 br Materials and methods br

  2023-07-25

  

  Materials and methods Results Discussion In this study, we have demonstrated that the adiponectin system (genes and proteins) is present in the porcine endometrium (epithelial glandular cells, luminal epithelial PQ 401 and stromal cells) and myometrium (longitudinal and circular muscle laye

• Perhaps the discovery of this linkage

  2023-07-25

  

  Perhaps the discovery of this linkage has served to catapult much of the work on ABCA1, leaving its family member in need of a relationship with a defined human pathology. In this regard, there is by now a quite mature literature that suggests that ABCA2 may have been overlooked in terms of its impo

• It could be hypothesized that the adiponectin system

  2023-07-25

  

  It could be hypothesized that the adiponectin system is regulated by gonadal steroid hormones. The lowest concentrations of adiponectin, AdipoR1 and AdipoR2 proteins in the endometrium and myometrium during the mid-luteal and late-luteal phases suggest that progesterone suppresses the expression of

• br ACK inhibitors Since ACK activation is correlated with po

  2023-07-25

  

  ACK1 inhibitors Since ACK1 activation is correlated with poor prognosis in various cancers, strong efforts are being directed by multiple groups towards developing highly potent and specific small molecule inhibitors targeting the ACK1 kinase. At least eight small molecule kinase inhibitors have

• br Discussion One binding site

  2023-07-25

  

  Discussion One binding site, MB327-1 (Fig. 4) is located in the extracellular domain between the γ and α subunits. MB327 adopts an extended conformation in the MB327-1 site and is oriented parallel to the channel. The second putative binding site, MB327-2 (Fig. 4) is situated deep inside the chan

• br Regulation and pharmacology of

  2023-07-25

  

  Regulation and pharmacology of mPGES-1 mPGES-1 (16 kDa, 152 amino acids) is a trimeric integral membrane protein of the endoplasmic reticulum with each monomer containing four transmembrane domains (Samuelsson et al., 2007; Sjogren et al., 2013). The three active site cavities are located at the

• In this paper we describe

  2023-07-24

  

  In this paper, we describe the formation of a structure-based pharmacophore which lead to the discovery of several hydrophobic, yet non-lipid inhibitors of ATX. These compounds docked within the same volume occupied by the initial non-lipid inhibitors of ATX used to build the pharmacophore. Violatio

• br Discussion In our current study we

  2023-07-24

  

  Discussion In our current study, we demonstrated that both the metastatic and recurrent ovarian cancer tissues expressed lower levels of p62 when compared with the patient-matched primary tumor samples. High glycoprotein iib iiia inhibitors levels of p62 were associated with long progression-fre

• Our results showed suppressed autophagy in GECs

  2023-07-24

  

  Our results showed suppressed autophagy in GECs under HAGG stimulation. Recently, people have paid more attentions on the roles of autophagy in lupus and tried to use autophagy regulators for therapy. Rapamycin could prevent the development of nephritis [49] and attenuate the established nephritis [

• Although CP has been an important research subject

  2023-07-24

  

  Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular Calmidazolium chloride by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an invo

• Conessine Pyrimidine is the important pharmacology core in

  2023-07-24

  

  Pyrimidine is the important pharmacology core in many Aurora inhibitors, such as VX-680, ENMD-2076, CYC-116 and ENMD-2076 [12]. To identify additional effective Aurora inhibitors, we designed a series of 2,4-diaminopyrimidine compounds, our modeling studies suggested that the Conessine core as well

• Solasodine Upregulation of ACLY is common

  2023-07-24

  

  Upregulation of ACLY is common in many cancers (Kuhajda, 2000, Milgraum et al., 1997, Swinnen et al., 2004, Yahagi et al., 2005). This is in part due to the transcriptional activation by SREBP-1 resulting from the activation of the PI3K/AKT pathway in cancers (Kim et al., 2010, Nadler et al., 2001,

• Then Autodock was employed for site directed

  2023-07-24

  

  Then, Autodock4.2 was employed for site directed docking on AD with the ligands of the cluster(s) having high binding affinities in VS II experiment (Morris et al., 2009). Docking protocols were followed as per our earlier report with 200 GA (genetic algorithm) run (Kalani et al., 2015). Likewise, l

16342 records 322/1090 page Previous Next First page 上5页 321322323324325 下5页 Last page