• Epigenetic drugs such as HDAC inhibitors regulate

  2021-09-14

  

  Epigenetic drugs, such as HDAC inhibitors, regulate gene expression by affecting the activity of histone or DNA modifying enzymes and their associated transcriptional response [141]. BET bromodomain protein inhibition is another epigenetic approach for blocking the Hedgehog pathway at the downstream

• It is important to clarify whether the decrease in USV

  2021-09-14

  

  It is important to clarify whether the decrease in USV after administration was secondary to the central depressant actions of the test compounds. Several reports have addressed the possibility that central depressant actions such as motor incoordination or changes in body temperature might affect U

• In contrast to short term effects long term

  2021-09-13

  

  In contrast to short-term effects, long-term exposure of beta cells to FFAs impairs insulin secretion and triggers apoptosis [13]. The deleterious effects of FFAs have been linked to altered glucose/fatty Ivabradine HCl oxidation cycle [13], decreased NADPH content [14], endoplasmic reticulum (ER)

• br Materials and methods br Results br Discussion

  2021-09-13

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast Octreotide acetate by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within m

• CGRP 8-37 (rat) sale In comparison to the standard HPLC assa

  2021-09-13

  

  In comparison to the standard HPLC assay to detect LPV above or below 1,000 ng mL-1, the accuracy of the PIs-IC strip was 97.8 %, the sensitivity was 100% and the specificity was 97.1 %. This suggests that the PIs-IC strip test has the potential accurately to semi-quantify PI concentrations in plas

• br Significance Cellular heterogeneity for phenotypic featur

  2021-09-13

  

  Significance Cellular heterogeneity for phenotypic features is a key mechanism underlying disease progression and therapeutic resistance, yet its regulation is poorly understood at the molecular level. Our findings demonstrate that endocrine resistance is associated with higher transcriptomic het

• In vitro studies suggest that the increase in

  2021-09-13

  

  In vitro studies suggest that the increase in Hx activity seen in normal pregnancy may contribute to the down-regulation of the vascular expression of Angiotensin II receptor 1 thereby promoting a relaxed and dilated maternal vascular bed [25]. It has further been suggested that the decreased Hx act

• IOX 1 br Hedgehog in chronic liver disease The liver

  2021-09-13

  

  Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li

• Under most circumstances NO is a potent endogenous vasodilat

  2021-09-13

  

  Under most circumstances, NO is a potent endogenous vasodilator. Therefore, its involvement in an endothelium-dependent contraction seems paradoxical, to say the least. Soluble guanylyl cyclase (sGC) is the major downstream target of NO; its inhibition results in the lack of vasoconstrictor response

• In addition to the role of

  2021-09-13

  

  In addition to the role of TGR5, the FXR-FGF15/19 axis has been implicated in other aspects of glucose metabolism and metabolic disorders. In humans, both obesity and type 2 diabetes mellitus (T2DM) are associated with lower plasma FGF19 levels [67,68]. A derivative of the naturally occurring FXR ag

• Interestingly mGlu and mGlu receptors differ

  2021-09-13

  

  Interestingly, mGlu2 and mGlu3 receptors differ notably by their cellular distribution. Whereas mGlu2 receptors are mostly neuronal, mGlu3 receptors are expressed both in glia and in neurons. In neurons, mGlu3 receptors are present at the post-synapse and in presynaptic elements (Tamaru et al., 2001

• br Introduction Maintaining blood glucose within

  2021-09-13

  

  Introduction Maintaining blood glucose within an appropriate range is crucial for survival. In diabetes, those who suffer episodes of severe hypoglycemia have an increased risk of death [1], [2]. The Hoechst 34580 is especially dependent on an adequate, continuous supply of circulating glucose t

• br Glucocorticoid receptor and metabolic syndrome GCs

  2021-09-13

  

  Glucocorticoid receptor and metabolic syndrome GCs acting through the GR regulate key enzymes of glucose metabolism in the liver, skeletal muscle, adipose tissue and the pancreas. In the liver, GCs regulate the expression of major gluconeogenic enzymes such as phosphoenolpyruvate carboxykinase, g

• br Materials Aspergillus oryzae GS U mg

  2021-09-13

  

  Materials Aspergillus oryzae βGS (8.4 U mg−1 solid) was obtained from Sigma-Aldrich Chemicals Co. (USA). o-Nitrophenyl β-d-galactopyranoside (ONPG), sodium carbonate, zinc chloride, manganese chloride, calcium chloride and potassium chloride were procured from Sisco Research Laboratories (SRL), M

• br Novel mechanisms of fipronil resistance in planthoppers

  2021-09-13

  

  Novel mechanisms of fipronil resistance in planthoppers Conclusion Conflict of interest Introduction Methamphetamine, a widely abused drug, is mainly used as a psychostimulant although it is occasionally used at low doses for medical purposes, such as in attention deficit or hyperactivit

16345 records 609/1090 page Previous Next First page 上5页 606607608609610 下5页 Last page